Metagenics TocoCare 30 Soft Capsules

Clinical Benefits
– The combination of 270 mg of citrus bioflavonoids and 18 mg of tocotrienols, has been shown to impact total cholesterol by an average of 25% over 4 weeks and 27% over 12 weeks: Three studies including a double blind, randomised clinical trial plus two open-label trials demonstrated significant reductions in total cholesterol, triglycerides and LDL:HDL ratio
– Key mechanisms include HMG-CoA reductase inhibition, reduction of apolipoprotein-B100 secretion and modulation of hepatic LDL receptors.2,3 Specifically, the polymethoxyflavones tangeretin and nobiletin, suppress the hepatic secretion of ApoB and increase LDL receptor synthesis. is an exclusive extract of citrus bioflavonoids containing at least 11.5 mg of tangeretin and 10 mg nobiletin per dose.
– Tocotrienols inhibit the production of HMGCoA reductase but support endogenous CoQ10 production via induction of the enzyme geranylgeranyl pyrophosphate (GGPP). In vitro research shows an 80% inhibition of HMG-CoA reductase by decreasing transcription efficiency and enhancing degradation, unlike most HMG-CoA reductase inhibitors which block the mevalonate pathway by up to 99%.