The efficacy of standard formulations of Berberine is limited due to low absorption and extensive breakdown after ingestion.† A study using liposomal delivery found administration of Liposomal Berberine in rats increased retention time in circulation from .42 to 10 hours (23-46x).†

The figure below shows the amount of liposomal Berberine formulations (yellow and orange bars) is higher in tissues and blood compared to a standard formulation (blue bar).

Standard Berberine has poor absorption and has less than 1%oral bioavailability, meaning its levels in the blood quickly diminish after ingestion.† To address this issue, LIPO Berberine uses an advanced liposomal delivery system designed to improve the bioavailability, created for better absorption, and a slower release into the bloodstream.†